The ML350 is standard with rear-wheel drive, with optional 4MATIC all-wheel drive, while 4MATIC is standard on the rest of the range. The ML350 comes with a 3.5L, 60-degree V6 with high-pressure direct injection, which results in 302 horsepower. The ML250 Blue TEC features a 2.1L turbocharged diesel 4-cylinder that delivers 200 horsepower and an impressive 369 foot-pounds of torque.
ML350 have only two rows of seating and can accommodate up to five adults. They're packaged much like other SUVs, which is to say that rear seatbacks fold forward along with the lower cushions to expand the cargo space up to 71 cubic feet. When the centre position of the back seat isn't being used, there's a fold-down centre armrest and cupholder. Upholstery is available either in a combination of MB Tex synthetic and a microfiber or in leather.
Ride quality of the ML 350 is smooth, quiet and absorbent, yet steering response is quite sharp. Safety features offered are Lane Keeping Assist, Blind Spot Assist, a Night View Assist night-vision system with pedestrian detection, Distronic Plus adaptive cruise control, a Pre-Safe Brake system that will help brake if a collision is anticipated and a special lighting package. Attention Assist studies patterns in the driver's fine steering adjustments, can identify fatigue and drowsiness, chiming and flashing a coffee cup icon on the instrument panel.